Mutations that disrupt biological rhythms have existed in microbial and metazoan eukaryotes for some time. They have recently begun to be studied with increasing intensity, both in terms of phenotypic effects of the relevant genetic variants, and with regard to molecular isolation and analysis of the genes defined by two of the ‘clock mutations’. These genetic loci, called period (per) in Drosophila and frequency (frq) in Neurospora, influence not only the basic characteristics of circadian rhythmicity, but also temperature compensation of (...) such daily cycle durations, ‘re‐setting’ of the rhythms' phases, and (for the per mutants) behavioral oscillations associated with much shorter than circadian periodicities. Molecular cloning of Drosophila's per gene, accompanied crucially by the locus's identification in germ‐line transformants, has led to information on its expression ‐ temporally, spatially, and in regard to heterogeneity of mRNA types. Nucleotide‐sequencing analyses of genomic DNA (and/or cDNA) from normal and mutated per alleles have (1) led to the suggestion that this clock gene encodes a family of proteoglycans (which was further indicated by application of antibody reagents obtained by manipulation of one of the gene's exons); and (2) shown that the three types of per mutations ‐ which shorten or lengthen rhythm periodicities or appear to eliminate them ‐ are associated with interesting amino‐acid substitutions or a stop codon, respectively. Analogous molecular findings are awaited from Neurospora, whose frq gene has very recently been cloned and definitively identified, in part via transformation experiments. (shrink)

Nostalgia is a fond longing for the past that has been shown to increase feelings of meaning, social connectedness, and self-continuity. Although nostalgia for personal memories provides intra- and interpersonal benefits, there may be negative consequences of group-based nostalgia on the perception and acceptance of others. The presented research examined national nostalgia, and its effects on group identification and political attitudes in the United States. In a sample of US voters, tendencies to feel personal and national nostalgia are associated with (...) markedly different emotional and attitudinal profiles. Higher levels of national nostalgia predicted both positive attitudes toward President Trump and racial prejudice, though there was no evidence of such relationships with personal nostalgia. National nostalgia most strongly predicted positive attitudes toward president Trump among those high in racial prejudice. Furthermore, nostalgia's positive relationship with racial prejudice was partially mediated by perceived outgroup threat. Results from this study will help us better understand how the experience of national nostalgia can influence attitudes and motivate political behavior. (shrink)

Belief in propositions has had a long and distinguished history in analytic philosophy. Three of the founding fathers of analytic philosophy, Gottlob Frege, Bertrand Russell, and G. E. Moore, believed in propositions. Many philosophers since then have shared this belief; and the belief is widely, though certainly not universally, accepted among philosophers today. Among contemporary philosophers who believe in propositions, many, and perhaps even most, take them to be structured entities with individuals, properties, and relations as constituents. For example, the (...) proposition that Glenn loves Tracy has Glenn, the loving relation, and Tracy as constituents. What is it, then, that binds these constituents together and imposes structure on them? And if the proposition that Glenn loves Tracy is distinct from the proposition that Tracy loves Glenn yet both have the same constituents, what is about the way these constituents are structured or bound together that makes them two different propositions? In The Nature and Structure of Content, Jeffrey C. King formulates a detailed account of the metaphysical nature of propositions, and provides fresh answers to the above questions. In addition to explaining what it is that binds together the constituents of structured propositions and imposes structure on them, King deals with some of the standard objections to accounts of propositions: he shows that there is no mystery about what propositions are; that given certain minimal assumptions, it follows that they exist; and that on his approach, we can see how and why propositions manage to have truth conditions and represent the world as being a certain way. The Nature and Structure of Content also contains a detailed account of the nature of tense and modality, and provides a solution to the paradox of analysis. Scholars and students working in the philosophy of mind and language will find this book rewarding reading. (shrink)

The works of Hannah Arendt and Albert Camus--two of the most compelling political thinkers of the "resistance generation" that lived through World War II--can still provide penetrating insights for contemporary political reflection. Jeffrey C. Isaac offers new interpretations of these writers, viewing both as engaged intellectuals who grappled with the possibilities of political radicalism in a world in which liberalism and Marxism had revealed their inadequacy by being complicit in the rise of totalitarianism. According to Isaac, self-styled postmodern writers (...) who proclaim the death of grandiose ideologies often fail to recognize that such thinkers as Camus and Arendt had already noted this. But unlike many postmodernists, these two sought to preserve what was worthy in modern humanism--the idea of a common human condition and a commitment to human rights and the dignity of individuals. Isaac shows that both writers advanced the idea of a democratic civil society made up of self-limiting groups. Although they criticized the typical institutions of mass democratic politics, they endorsed alternative forms of local and international organization that defy the principle of state sovereignty. Isaac also shows how Arendt's writings on the Middle East, and Camus's on Algeria, urged the creation of such institutions. The vision of a "rebellious politics" that Arendt and Camus shared is of great relevance to current debates in democratic theory and to the transformations taking place in Europe and the states of the former Soviet Union. (shrink)

Philosophy, science, and common sense all refer to propositions--things we believe and say, and things which are true or false. But there is no consensus on what sorts of things these entities are. Jeffrey C. King, Scott Soames, and Jeff Speaks argue that commitment to propositions is indispensable, and each defend their own views on the debate.

result from combining the determiners `this' or `that' with syntactically simple or complex common noun phrases such as `woman' or `woman who is taking her skis off'. Thus, `this woman', and `that woman who is taking her skis off' are complex demonstratives. There are also plural complex demonstratives such as `these skis' and `those snowboarders smoking by the gondola'. My book Complex Demonstratives: A Quantificational Account argues against what I call the direct reference account of complex demonstratives (henceforth DRCD) and (...) defends a quantificational account of complex demonstratives. In two recent papers, Nathan Salmon has criticized one of the book's arguments against DRCD. In this essay I show that Salmon's criticism fails. I also show that the version of DRCD that Salmon ends up endorsing is false. (shrink)

Main deficiency of active people. Active men are usually lacking in higher activity—I mean, individual activity. They are active as officials, businessmen, scholars, that is, as generic beings....Active people roll like a stone, conforming to the stupidity of mechanics. Friedrich Nietzsche, Human, All Too Human.

A defining characteristic of Alzheimer’s disease is difficulty in retrieving semantic memories, or memories encoding facts and knowledge. While it has been suggested that this impairment is caused by a degradation of the semantic store, the precise ways in which the semantic store is degraded are not well understood. Using a longitudinal corpus of semantic fluency data, we derive semantic network representations of patients with Alzheimer’s disease and of healthy controls. We contrast our network-based approach with analyzing fluency data with (...) the standard method of counting the total number of items and perseverations in fluency data. We find that the networks of Alzheimer’s patients are more connected and that those connections are more randomly distributed than the connections in networks of healthy individuals. These results suggest that the semantic memory impairment of Alzheimer’s patients can be modeled through the inclusion of spurious associations between unrelated concepts in the semantic store. We also find that information from our network analysis of fluency data improves prediction of patient diagnosis compared to traditional measures of the semantic fluency task. (shrink)

Although some critics of Eric Voegelin’s later work have faulted his failure to deal with the historical Jesus and to address the implications of Christianity for social and political life, the recent publication of Voegelin’s _History of Political Ideas_ has allowed a more complete assessment of his position regarding the Christian political order. This book addresses that criticism through an analysis of Voegelin’s early work. In _Eric Voegelin and the Problem of Christian Political Order_, Jeffrey C. Herndon analyzes the (...) development of Voegelin’s thought regarding the origins of Christianity in the person of Jesus, the development of the church in the works of Paul, and the relationship between an immanent institutional order symbolizing the divine presence and the struggle for social and political order. Focusing on the tension between a spiritual phenomenon based on Pauline faith and the institutionalization of that experience in the church, Herndon offers one of the first examinations of the relationship of the _History of Political Ideas_ to Voegelin’s larger body of work. In his wide-ranging study, Herndon explores Voegelin’s examination of the problem of Christian political order from the inception of Christianity through the Great Reformation. He also presents a clarification of Voegelin’s theory of civilizational foundation and of Voegelin’s philosophy of history with regard to Christianity and Western political order. Herndon addresses not only the nagging problem in Voegelin scholarship regarding his relationship with the historical Jesus but also the “Pauline compromises with the world” that enabled Christianity to become the instrument by which the West was civilized. He also shows that Voegelin’s interpretation of the historical pressures released by the Great Reformation is important to an understanding of his later work regarding the negative effect of Christian symbols in the creation of ideological disorder. _Eric Voegelin and the Problem of Christian Political Order_ clarifies issues in Voegelin studies regarding the intersection between political theory and Christian concerns, addressing the relation of religious experience to the public sphere of political life in the West and helping to explain Voegelin’s contention that the death of the spirit is the price of progress. It offers scholars a perspective heretofore lacking in Voegelin scholarship and a clearer view of Voegelin’s understanding of the Christian dispensation and its influence on the course of Western development, history, and philosophy. (shrink)

At least since Russell’s influential discussion in The Principles of Mathematics, many philosophers have held there is a problem that they call the problem of the unity of the proposition. In a recent paper, I argued that there is no single problem that alone deserves the epithet the problem of the unity of the proposition. I there distinguished three problems or questions, each of which had some right to be called a problem regarding the unity of the proposition; and I (...) showed how the account of propositions formulated in my book The Nature and Structure of Content [2007 Oxford University Press] solves each of these problems. In the present paper, I take up two of these problems/questions yet again. For I want to consider other accounts of propositions and compare their solutions to these problems, or lack thereof, to mine. I argue that my account provides the best solutions to the unity problems. (shrink)

In this study, we used Terrance L. Furin’s concept of transformational countering to examine six Holocaust education resources designed to address Holocaust trivialization and antisemitism. While academic comparisons are useful to helping students understand challenging content, superficial Holocaust analogies for political purposes are identified as Holocaust trivialization. Given that the current context consists of a growing white nationalist movement characterized by authoritarianism, antisemitism, and conspiracy theories, we enter the study understanding that Holocaust trivialization and far-right extremism must be understood together. (...) We, therefore, examined the type of support teachers receive from Holocaust and human rights organizations in countering extremism and Holocaust trivialization. After analyzing the six resources, our findings demonstrate that resources produced to counter Holocaust trivialization become quickly outdated given the rapid evolution of extremism. Also, findings indicate that teachers receive stronger support in countering extremism and Holocaust trivialization from organizations that focus broadly on supporting human rights compared to the organizations that focus exclusively on Holocaust education. (shrink)

A challenge to the orthodoxy, which shows that quantificational accounts are not only as effective as direct reference accounts but also handle a wider range of ...

To show the importance of preparing historical editions as textual data first, while leaving presentation (whether in print or on the web) as a secondary down-stream task, this article identifies beneficial outcomes for research that can be achieved through computational analysis when such a corpus of textual data is at hand. With a focus on the deep intertextuality characteristic of the medieval scholastic corpus, it reviews three distinct methods for detecting different forms of textual relatedness within the corpus: n-gram intersections, (...) document embeddings, and convolution. In each case, special attention is given to how the availability of a domain specific knowledge graph helps us both properly prepare the corpus for analysis and visualize the results in ways that enhance research. Such results include observing trends in citation practices across different genres and sub-genres of the corpus, automatically grouping questions by similarity, and detecting sustained and uncited textual re-use. (shrink)

As social theorists seek to understand the contemporary challenges of radical populism, we would do well to reconsider the febrile insights of the psychoanalytic social theorist Erich Fromm. It was Fromm who, at the beginning of the 1930s, conceptualized the emotional and sociological roots of a new ‘authoritarian character’ who was meek in the face of great power above and ruthless to the powerless below. It was Fromm, in the 1950s, who argued that societies, not only individuals, could be sick. (...) This essay traces the intertwining of psychoanalytic and sociological methods that allowed Fromm to create such new ideas. At the same time, it highlights how Fromm’s sociology was hampered by an economistic Marxist approach to the institutions and culture of democratic capitalist societies. Such theoretical restriction prevented Fromm from conceptualizing how institutions like democracy, science, and psychotherapy can provide resources for widespread emotional recuperation and civil repair. (shrink)

Cultural trauma occurs when members of a collectivity feel they have been subjected to a horrendous event that leaves indelible marks upon their group consciousness, marking their memories forever and changing their future identity in fundamental and irrevocable ways. While this new scientific concept clarifies causal relationships between previously unrelated events, structures, perceptions, and actions, it also illuminates a neglected domain of social responsibility and political action. By constructing cultural traumas, social groups, national societies, and sometimes even entire civilizations, not (...) only cognitively identify the existence and source of human suffering, but may also take on board some significant moral responsibility for it. Insofar as they identify the cause of trauma in a manner that assumes such moral responsibility, members of collectivities define their solidary relationships that allow them to share the suffering of others. Is the suffering of others also our own? In thinking that it might in fact be, societies expand the circle of the ‘we’ and create the possibility for repairing societies to prevent the trauma from happening again. By the same token, social groups can, and often do, refuse to recognize the existence of others’ suffering, or place the responsibility for it on people other than themselves. Empirically, this article extensively considers trauma construction in the case of the Holocaust – the mass murder of Jews by the German Nazis – but also examines trauma processes in relation to African-Americans, indigenous peoples, colonial victims of Western and Japanese imperialism, the Nanjing Massacre, and victims of the early communist regimes in Soviet Russia and Maoist China. (shrink)

In The Principles of Mathematics, Bertrand Russell famously puzzled over something he called the unity of the proposition. Echoing Russell, many philosophers have talked over the years about the question or problem of the unity of the proposition. In fact, I believe that there are a number of quite distinct though related questions all of which can plausibly be taken to be questions regarding the unity of propositions. I state three such questions and show how the theory of propositions defended (...) in my recent book The Nature and Structure of Content answers them. (shrink)

CITATION: Ewuoso, C., Hall, S. & Dierickx, K. 2017. How do healthcare professionals manage ethical challenges regarding information in healthcare professional/patient clinical interactions? a review of concept- or argument-based articles and case analyses. South African Journal of Bioethics and Law, 10:75-82, doi:10.7196/SAJBL.2017.v10i2.610.

Semantics is the discipline that studies linguistic meaning generally, and the qualification ‘formal’ indicates something about the sorts of techniques used in investigating linguistic meaning. More specifically, formal semantics is the discipline that employs techniques from symbolic logic, mathematics, and mathematical logic to produce precisely characterized theories of meaning for natural languages or artificial languages. Formal semantics as we know it first arose in the twentieth century. It was made possible by certain developments in logic during that period. This article (...) chronicles those developments and how they led to the development of formal semantics. (shrink)

This essay examines conceptual metaphors from Śaiva-Śākta traditions of Hindu tantra. It explores how conceptual metaphors associated with heterodox ritual exchanges between humans and fierce divinities were employed and used to transform other ideas to express a new kind of kinship or family that replaced or supplemented orthodox concepts. It then considers the combination or blending of these conceptual systems with other ideas about concentration and miniaturization. The resulting conceptual metaphors are then directly related to the way that tantric traditions (...) moved over time to semanticized, abstract, orthodox, and mystical expressions and concepts. There is a diverse body of scholarship that examines and interprets the historical traditions of Hindu tantra. This body of scholarship is seldom considered outside of conversations among area specialists. Some of this is due to the heterodox nature of some tantric practices, especially concepts or rituals that use sex or sexual symbolism. Tantric focus on these heterodox conceptual frameworks conflicts directly with purity-oriented conceptual systems of orthodox Hindu traditions. Through a kind of meta-analysis of some of these conceptual metaphors, this essay seeks to consider a kind of conceptual logic that makes their heterodox content more understandable and accessible to other areas of religious studies and philosophy. The study relies on certain insights drawn from metaphor theory to formulate the concepts it examines. (shrink)

"Neofunctionalism and After" brings together for the first time in one volume all of Alexander's writings on neofunctionalism, the present volume also contains ...

This book argues that contextually sensitive expressions have felicitous uses in which they lack unique semantic values in context. It formulates a rule for updating the Stalnakerian common ground in cases in which an accepted sentence contains an expression lacking a unique semantic value in context.